null

FADD Rabbit Polyclonal Antibody (CAB20252)

SKU:
CAB20252
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Mort1/F
Mort1/FADD
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:FADD Rabbit Polyclonal Antibody
SKU:CAB20252
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1).
Sequence:MDPF LVLL HSLS GSLS GNDL MELK FLCR ERVS KRKL ERVQ SGLD LFTV LLEQ NDLE RGHT GLLR ELLA SLRR HDLL QRLD DFEA GTAT AAPP GEAD LQVA FDIV CDNV GRDW KRLA RELK VSEA KMDG IEEK YPRS LSER VRES LKVW KNAE KKNA SVAG LVKA LRTC RLNL VADL VEEA QESV SKSE NMSP VLRD STVS SSET P
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells
Synonyms:Mort1/FADD; FADD
Positive Sample:Jurkat,Mouse heart
Conjugate:Unconjugated
Cellular Localization:cytoplasm, cytosol, neuron projection, nucleus, plasma membrane, ripoptosome
Calculated MW:23kDa
Observed MW:28kDa

Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain).

Purification Method:Affinity purification
Gene ID:14082
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse heart, using FADD Rabbit pAb (CAB20252) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

Related Products