The FADD Polyclonal Antibody (CAB19838) is a valuable tool for researchers studying FADD (Fas-associated death domain protein), a key regulator of apoptosis and immune signaling pathways. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the FADD protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.
FADD is essential for the activation of apoptosis in response to various cellular signals, playing a crucial role in maintaining tissue homeostasis and eliminating damaged or infected cells. Dysregulation of FADD signaling has been implicated in the development of cancer and autoimmune diseases, highlighting its importance as a therapeutic target. Research into the function and regulation of FADD is pivotal for advancing our understanding of these conditions and developing novel treatment strategies.
Product Name:
FADD Rabbit Monoclonal Antibody
SKU:
CAB19838
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of mouse FADD (NP_034305.1).
Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain).
Purification Method:
Affinity purification
Gene ID:
14082
Clone Number:
ARC51937
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using FADD Rabbit mAb (CAB19838) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
