The Anti-ERAB/HSD17B10 Antibody (CAB0959) is a valuable tool for researchers studying ERAB/HSD17B10, a key enzyme involved in lipid metabolism and mitochondrial function. This polyclonal antibody, generated in rabbits, is highly specific to human ERAB/HSD17B10 and is validated for use in Western blot applications.ERAB/HSD17B10 plays a critical role in maintaining cellular lipid homeostasis and energy metabolism, making it a potential target for therapeutic interventions in metabolic disorders and cancer. By specifically binding to the ERAB/HSD17B10 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolism, mitochondrial function, and cancer biology.
Understanding the function and regulation of ERAB/HSD17B10 is essential for unraveling its role in lipid metabolism and mitochondrial function, and for developing targeted therapies for diseases associated with dysregulated lipid metabolism. The Anti-ERAB/HSD17B10 Antibody (CAB0959) is a valuable tool for researchers investigating the intricate connections between lipid metabolism, mitochondrial function, and disease pathology.
Product Name:
ERAB/HSD17B10 Rabbit Monoclonal Antibody
SKU:
CAB0959
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 162-261 of human ERAB/HSD17B10 (Q99714).
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Purification Method:
Affinity purification
Gene ID:
3028
Clone Number:
ARC1852
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ERAB/HSD17B10 Rabbit mAb (CAB0959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
