The Anti-Ephrin-A1 Antibody (CAB9132) is a high-quality research tool designed for the study of ephrin-A1, a cell surface protein involved in cell signaling and regulation. This antibody is produced in rabbits and is specifically reactive with human samples, making it a reliable tool for various research applications.Ephrin-A1 plays a crucial role in cell-to-cell communication and is known to be involved in processes such as cell growth, migration, and tissue development. The Anti-Ephrin-A1 Antibody binds specifically to the ephrin-A1 protein, allowing for the detection and analysis of this molecule in different cell types and tissues.
This antibody is validated for use in techniques such as Western blotting, immunohistochemistry, and immunofluorescence, making it versatile for researchers studying ephrin-A1 in the fields of neuroscience, developmental biology, and cancer research. By understanding the function and expression of ephrin-A1, researchers can gain insights into various biological processes and potentially develop new therapeutic strategies targeting this protein.
Product Name:
Ephrin A1 Rabbit mAb
Product Code:
CAB9132
Size:
20uL, 50uL, 100uL
Synonyms:
B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4
Applications:
WB, IHC, IF
Reactivity:
Human, Mouse
Host Species:
Rabbit
Immunogen:
A synthesized peptide derived from human Ephrin A1
A synthesized peptide derived from human Ephrin A1
Purification Method:
Affinity purification
Storage:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
1942
Uniprot:
P20827
Calculated MW:
24kDa
Observed MW:
25KDa
UniProt Protein Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
NCBI Summary:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
