EPHA3/EPHA4/EPHA5 Polyclonal Antibody (CAB20254)
- SKU:
- CAB20254
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | EPHA3/EPHA4/EPHA5 Polyclonal Antibody |
SKU: | CAB20254 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human EPHA3/EPHA4/EPHA5 (NP_005224.2). |
Sequence: | EYME NGSL DSFL RKHD AQFT VIQL VGML RGIA SGMK YLSD MGYV HRDL AARN ILIN SNLV CKVS DFGL SRVL EDDP EAAY TTRG GKIP IRWT SPEA IAYR K |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, cytosol, early endosome, extracellular region, nuclear membrane, nucleoplasm, plasma membrane |
Observed MW: | Refer to figures |
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Purification Method: | Affinity purification |
Gene ID: | 2042/2043/2044 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |