The Anti-EpCAM Antibody (CAB19301) is a high-quality, polyclonal antibody designed for research involving EpCAM, a cell surface protein associated with various cancers and stem cells. The antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in immunohistochemistry and flow cytometry applications. It specifically binds to the EpCAM protein, allowing for accurate detection and analysis in different cell types.EpCAM, also known as CD326, is a transmembrane glycoprotein that plays a crucial role in cell adhesion and signaling pathways. Its overexpression has been linked to tumor progression and metastasis in multiple cancer types, making it a promising target for cancer therapy research.
Understanding the functions and mechanisms of EpCAM can provide valuable insights into cancer biology and potential treatment strategies.This Anti-EpCAM Antibody is a valuable tool for researchers studying EpCAM expression, localization, and interactions in cancer cells and stem cells. Its high specificity and sensitivity make it a reliable choice for investigating the role of EpCAM in tumorigenesis, metastasis, and therapeutic resistance. With its proven performance in various research applications, this antibody is a valuable addition to any immunology or cancer research laboratory.
Product Name:
EpCAM Rabbit Monoclonal Antibody
SKU:
CAB19301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 215-314 of human EpCAM (P16422).
Cell junction, Lateral cell membrane, Single-pass type I membrane protein, tight junction.
Calculated MW:
35kDa
Observed MW:
Refer to figures
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Purification Method:
Affinity purification
Gene ID:
4072
Clone Number:
ARC0277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using EpCAM Rabbit mAb (CAB19301) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
