The Anti-Engrailed-1 Antibody (CAB19672) is a highly specific tool for researchers studying the Engrailed-1 protein, which plays a key role in neural development and patterning in vertebrates. This antibody, generated in rabbits, has been validated for use in various applications including Western blot and immunohistochemistry. It binds specifically to the Engrailed-1 protein, allowing for precise detection and analysis in different cell types and tissues.Engrailed-1 is a transcription factor that regulates gene expression and is essential for the development of the central nervous system. Dysregulation of Engrailed-1 has been implicated in various neurological disorders, making it a valuable target for studies in neuroscience and developmental biology.
By understanding the function of Engrailed-1, researchers can gain insights into neurodevelopmental processes and potentially identify therapeutic targets for neurological diseases.Overall, the Anti-Engrailed-1 Antibody (CAB19672) is a reliable tool for investigating the role of Engrailed-1 in neural development and function, offering valuable insights that may contribute to the development of treatments for neurological disorders.
Product Name:
Engrailed 1 Rabbit Monoclonal Antibody
SKU:
CAB19672
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 293-392 of human Engrailed 1 (Q05925).
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
Purification Method:
Affinity purification
Gene ID:
2019
Clone Number:
ARC2225
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Engrailed 1 Rabbit mAb (CAB19672) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
