Based on the information in the provided URL, I have written a product description for the Anti-EIF2B Epsilon (EIF2B5) antibody CAB8670:The Anti-EIF2B Epsilon (EIF2B5) Polyclonal Antibody (CAB8670) is specially designed for research involving EIF2B5, a key subunit of the eukaryotic translation initiation factor 2B (eIF2B) complex. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. With a high specificity for EIF2B5, this antibody allows for the detection and analysis of EIF2B5 protein levels in various cell types, making it an essential tool for studies in molecular biology and disease research.
EIF2B5 is a critical component of the eIF2B complex, which plays a crucial role in the regulation of protein synthesis and cellular stress responses. Dysregulation of EIF2B5 has been implicated in various diseases, including leukoencephalopathy with vanishing white matter (VWM), a rare genetic disorder affecting the central nervous system. Research on EIF2B5 can provide valuable insights into the molecular mechanisms underlying these diseases, leading to potential therapeutic interventions targeting the eIF2B complex.By utilizing the Anti-EIF2B Epsilon (EIF2B5) Polyclonal Antibody (CAB8670), researchers can further explore the
Product Name:
eIF2B epsilon (EIF2B5) Rabbit Monoclonal Antibody
SKU:
CAB8670
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human eIF2B epsilon (EIF2B5) (EIF2B5) (Q13144).
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
Purification Method:
Affinity purification
Gene ID:
8893
Clone Number:
ARC1774
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using eIF2B epsilon (EIF2B5) (EIF2B5) Rabbit mAb (CAB8670) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
