The EI24 Polyclonal Antibody (CAB19437) is a valuable tool for researchers studying the EI24 protein, which is involved in autophagy and cell death pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for Western blotting applications. By binding specifically to EI24, this antibody allows for precise detection and analysis of the protein in a variety of cell types.EI24, also known as etoposide-induced 2.4 mRNA, plays a crucial role in maintaining cellular homeostasis by regulating autophagy, a process vital for removing damaged organelles and proteins.
Dysregulation of autophagy has been implicated in various diseases, including cancer and neurodegenerative disorders. By studying the function of EI24, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.The EI24 Polyclonal Antibody is a valuable tool for investigating the role of EI24 in autophagy and cell death pathways, making it an essential component of research in cell biology, cancer biology, and neurodegenerative diseases.
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8.
Purification Method:
Affinity purification
Gene ID:
9538
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using EI24 Rabbit pAb (CAB19437) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
