The EGR2 Polyclonal Antibody (CAB3219) is a valuable tool for research involving EGR2, a transcription factor known for its role in nerve myelination and immune system regulation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the EGR2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in neurobiology, immunology, and autoimmune diseases.EGR2, also known as early growth response protein 2, is a key player in the regulation of gene expression and cell differentiation, particularly in the nervous and immune systems.
Its involvement in myelin formation and immune response modulation makes it a promising target for research into neurological disorders, autoimmune conditions, and inflammatory diseases. Understanding the function of EGR2 is essential for developing novel therapeutic strategies that target these pathways for potential treatment options.
Product Name:
EGR2 Rabbit Monoclonal Antibody
SKU:
CAB3219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EGR2 (NP_000390.2).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells
Synonyms:
AT591; CMT1D; CMT4E; KROX20; EGR2
Positive Sample:
SH-SY5Y,Mouse brain,Rat brain
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
50kDa
Observed MW:
53kDa
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1959
Clone Number:
ARC1932
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using EGR2 Rabbit mAb (CAB3219) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
