E2F4 Monoclonal Antibody (CAB19670)
- SKU:
- CAB19670
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- E2F-4
Description
Product Name: | E2F4 Monoclonal Antibody |
SKU: | CAB19670 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human E2F4 (Q16254). |
Sequence: | TAVP GSAE VQGM AGPA AEIT VSGG PGTD SKDS GELS SLPL GPTT LDTR PLQS SALL DSSS SSSS SSSS SSNS NSSS SSGP NPST SFEP IKAD PTGV LELP K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | E2F-4; E2F4 |
Positive Sample: | HT-1080,Mouse lung,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, nucleoplasm |
Calculated MW: | 44kDa |
Observed MW: | 62kDa |
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Purification Method: | Affinity purification |
Gene ID: | 1874 |
Clone Number: | ARC2223 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |