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Anti-E2F2 Antibody (CAB3297)

SKU:
CAB3297
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
E2F-2
Research Area:
Cell Cycle
€139 - €419
Frequently bought together:

Description

Anti-E2F2 Antibody (CAB3297)

The Anti-E2F2 Polyclonal Antibody (CAB3297) is a valuable tool for researchers studying the E2F2 protein, a transcription factor involved in cell cycle regulation and apoptosis. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the E2F2 protein, this antibody facilitates the detection and analysis of E2F2 in various cell types, making it an essential tool for studies in molecular biology and cancer research.E2F2 is a key regulator of cell proliferation and differentiation, playing a crucial role in maintaining genomic stability and tissue homeostasis.

Dysregulation of E2F2 has been implicated in various types of cancer, making it a promising target for therapeutic intervention. By studying the function and expression of E2F2, researchers can gain valuable insight into the mechanisms underlying tumorigenesis and potentially identify novel strategies for cancer treatment. Overall, the Anti-E2F2 Polyclonal Antibody (CAB3297) offers researchers a reliable and specific tool for investigating the role of E2F2 in cellular processes, ultimately contributing to advancements in cancer biology and drug discovery.

Product Name:E2F2 Rabbit mAb
Product Code:CAB3297
Size:20uL, 50uL, 100uL
Synonyms:E2F-2
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human E2F2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, SH-SY5Y, Mouse lung, Mouse thymus
Immunogen:A synthesized peptide derived from human E2F2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1870
Uniprot:Q14209
Calculated MW:47kDa
Observed MW:50kDa
UniProt Protein Function:E2F2: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner. Belongs to the E2F/DP family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function:protein binding; DNA binding; transcription factor binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle

NCBI Summary:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
UniProt Code:Q14209
NCBI GenInfo Identifier:2494228
NCBI Gene ID:1870
NCBI Accession:Q14209.1
UniProt Secondary Accession:Q14209,Q7Z6H1, B2R9W1,
UniProt Related Accession:Q14209
Molecular Weight:47,506 Da
NCBI Full Name:Transcription factor E2F2
NCBI Synonym Full Names:E2F transcription factor 2
NCBI Official Symbol:E2F2  
NCBI Official Synonym Symbols:E2F-2  
NCBI Protein Information:transcription factor E2F2
UniProt Protein Name:Transcription factor E2F2
Protein Family:Transcription factor
UniProt Gene Name:E2F2  
UniProt Entry Name:E2F2_HUMAN

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