The Dynein Intermediate Chain 1 Polyclonal Antibody (CAB3624) is a valuable tool for researchers studying the dynein motor protein complex. Dynein is essential for various cellular processes, including intracellular transport, mitosis, and ciliary movement. This antibody, developed in rabbits, specifically targets the dynein intermediate chain 1 protein and has been validated for use in Western blot applications.By detecting and measuring levels of dynein intermediate chain 1, researchers can gain insights into the function and regulation of the dynein motor complex in different cell types and tissues.
This antibody is particularly useful for investigating dynein-related mechanisms in diseases such as neurodegenerative disorders, developmental abnormalities, and ciliary dysfunction.With its high reactivity towards human samples, the Dynein Intermediate Chain 1 Polyclonal Antibody offers researchers a reliable tool for advancing their understanding of dynein biology and its implications in health and disease.
This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
27019
Clone Number:
ARC2061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Dynein intermediate chain 1 antibody (CAB3624) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
