The Anti-DNMT1 Antibody (CAB15050) is a valuable tool for researchers studying DNA methyltransferase 1 (DNMT1), a key enzyme involved in DNA methylation and gene regulation. This antibody is raised in rabbits and is highly specific for detecting DNMT1 in human samples, making it an ideal choice for Western blot applications.DNMT1 plays a critical role in maintaining DNA methylation patterns during cell division, and dysregulation of this enzyme has been implicated in various diseases, including cancer and neurological disorders.
By targeting DNMT1 with this antibody, researchers can explore its role in epigenetic modifications and potentially uncover new therapeutic targets.With its high reactivity and specificity, the Anti-DNMT1 Antibody (CAB15050) is a valuable tool for studying epigenetic regulation and its role in disease development. Researchers in the fields of oncology, neurology, and epigenetics will find this antibody essential for their studies.
Product Name:
DNMT1 Polyclonal Antibody
SKU:
CAB15050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of DNMT1 (NP_001370.1).
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNMT1 Rabbit pAb (CAB15050) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
