DNA Polymerase gamma Rabbit Monoclonal Antibody (CAB1323)
The Anti-DNA Polymerase Gamma Antibody (CAB1323) is a valuable tool for researchers studying DNA polymerase gamma, an enzyme essential for mitochondrial DNA replication and repair. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications.DNA polymerase gamma is a key player in maintaining the integrity of mitochondrial DNA, making it critical for cellular energy production and overall mitochondrial function. Dysregulation of this enzyme has been implicated in various diseases, including mitochondrial disorders and certain types of cancer.
By targeting DNA polymerase gamma with this antibody, researchers can gain valuable insights into the role of this enzyme in disease pathology and potential therapeutic interventions.This antibody enables the detection and analysis of DNA polymerase gamma in various cell types, making it a versatile tool for studies in molecular biology, genetics, and mitochondrial research. With its high specificity and sensitivity, the Anti-DNA Polymerase Gamma Antibody is an essential component for unraveling the complexities of mitochondrial DNA maintenance and its implications for human health.
Product Name:
DNA Polymerase gamma Rabbit Monoclonal Antibody
SKU:
CAB1323
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1140-1239 of human DNA Polymerase gamma (P54098).
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5428
Clone Number:
ARC1871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using DNA Polymerase gamma Rabbit mAb (CAB1323) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
