The Anti-DKK1 Recombinant Rabbit Monoclonal Antibody (HDAB0201) is a valuable tool for researchers studying DKK1, a secreted protein involved in the regulation of Wnt signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards DKK1 in human samples, making it suitable for various research applications, including Western blotting.DKK1 is a key player in the modulation of Wnt signaling, which has been implicated in various physiological processes, including embryonic development, tissue homeostasis, and tumorigenesis. Dysregulation of DKK1 has been linked to diseases such as cancer, osteoporosis, and Alzheimer's disease, highlighting the importance of studying its function and expression levels.
By using the Anti-DKK1 Recombinant Rabbit Monoclonal Antibody, researchers can accurately detect and quantify DKK1 protein levels in different cell types and tissues, aiding in the understanding of its role in disease pathology and potential therapeutic interventions. This antibody is a valuable resource for investigations into the molecular mechanisms underlying Wnt signaling dysregulation and its impact on human health.
SKU:
HDAB0201
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM210
Synonyms:
DKK-1, SK
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
