The Anti-Digoxin Antibody (CAB20267) is a highly specific research tool designed for detecting and analyzing digoxin, a medication commonly used to treat heart conditions. The antibody, produced in rabbits, is reactive with digoxin in various samples and is validated for use in applications such as ELISA and immunohistochemistry.Digoxin is a cardiac glycoside that works by increasing the force of contraction of the heart muscle, making it an important medication for managing heart failure and certain arrhythmias.
Research on digoxin is essential for understanding its mechanisms of action, potential side effects, and optimizing treatment strategies.This antibody allows for precise detection and quantification of digoxin in biological samples, providing valuable insights for pharmacological studies, toxicological assessments, and clinical investigations. Its high specificity and sensitivity make it a reliable tool for researchers in the fields of pharmacology, cardiology, and drug development.
Product Name:
Digoxin Rabbit Monoclonal Antibody
SKU:
CAB20267
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Species independent
Immunogen:
Digoxin
Sequence:
Digo xin conj ugat ed t o KL H
Tested Applications:
ELISADB
Recommended Dilution:
DB,1:500 - 1:3000
Positive Sample:
Digoxin
Conjugate:
Unconjugated
Observed MW:
Refer to figures
Digoxin is a cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c, caspases 8 and 3.
Purification Method:
Affinity purification
Clone Number:
ARC50289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
The Digoxin Rabbit mAb (CAB20267) are tested in Dot Blot against digoxin labelled oligonucleotide(Dig-1，Dig-2 and Dig-3) and unlabelled oligonucleotide(Dig-4) Dig-1 :5'AGCTAAC/iDigdT/ACTAGCT(Biotin)3' Dig-2 :5'(Digoxin)AGCTAACTACTAGCT(Biotin)3' Dig-3 :5'(Biotin)AGCTAACTACTAGCT(Digoxin)3' Dig-4 :5'AGCTAACTACTAGCT(Biotin)3'
