The Anti-Desmoglein 2 Antibody (CAB4489) is a valuable tool for researchers studying autoimmune diseases, specifically those involving desmoglein 2, a cell adhesion molecule found in the skin and heart tissues. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.Desmoglein 2 plays a crucial role in maintaining the structural integrity of epithelial cells, particularly in the skin and heart. Dysregulation of desmoglein 2 has been implicated in autoimmune conditions such as pemphigus vulgaris, where autoantibodies target desmoglein 2, leading to loss of cell-cell adhesion and blister formation.
By utilizing the Anti-Desmoglein 2 Antibody, researchers can accurately detect and analyze desmoglein 2 expression in different cell types and tissue samples. This antibody is an essential tool for investigating the role of desmoglein 2 in autoimmune diseases and developing targeted therapies to modulate its activity. Researchers studying conditions like pemphigus vulgaris and other autoimmune disorders will find this antibody invaluable in their research efforts.
Product Name:
Desmoglein 2 Rabbit Monoclonal Antibody
SKU:
CAB4489
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1001-1118 of human Desmoglein 2 (Q14126).
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
Purification Method:
Affinity purification
Gene ID:
1829
Clone Number:
ARC1064
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Desmoglein 2 antibody (CAB4489) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
