Desmocollin 3 Rabbit Monoclonal Antibody (CAB0445)
- SKU:
- CAB0445
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | Desmocollin 3 Rabbit Monoclonal Antibody |
SKU: | CAB0445 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 797-896 of human Desmocollin 3 (Q14574). |
Sequence: | HHHT LDSC RGGH TEVD NCRY TYSE WHSF TQPR LGEK LHRC NQNE DRMP SQDY VLTY NYEG RGSP AGSV GCCS EKQE EDGL DFLN NLEP KFIT LAEA CTKR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; Desmocollin 3 |
Positive Sample: | TE-1 |
Conjugate: | Unmodified |
Cellular Localization: | Cell junction, Cell-cell junction, Cytoplasm, Desmosome, Extracellular region, Plasma membrane |
Calculated MW: | 100kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1825 |
Clone Number: | ARC2506 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |