The Anti-DEK Antibody (CAB0315) is a high-quality research tool designed for the detection and analysis of DEK protein in various cell types. This polyclonal antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. The DEK protein is a nuclear phosphoprotein that has been implicated in various cellular processes, including chromatin remodeling, DNA repair, and mRNA splicing. Dysregulation of DEK has been associated with cancers, autoimmune diseases, and inflammatory conditions, highlighting its importance in disease pathology.
Researchers studying DEK can benefit from the sensitivity and specificity of this antibody, which enables precise detection and quantification of DEK levels in experimental samples. By understanding the role of DEK in cellular function and disease development, researchers can uncover potential therapeutic targets and diagnostic biomarkers for various conditions.
Product Name:
DEK Rabbit Monoclonal Antibody
SKU:
CAB0315
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 51-200 of human DEK (P35659).
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7913
Clone Number:
ARC1825
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using DEK Rabbit mAb (CAB0315) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
