Daxx Rabbit Monoclonal Antibody (CAB19661)
- SKU:
- CAB19661
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BING2
- DAP6
- EAP1
Description
Product Name: | Daxx Rabbit Monoclonal Antibody |
SKU: | CAB19661 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Daxx (Q9UER7). |
Sequence: | AEIR RLQE KELD LSEL DDPD SAYL QEAR LKRK LIRL FGRL CELK DCSS LTGR VIEQ RIPY RGTR YPEV NRRI ERLI NKPG PDTF PDYG DVLR AVEK AAAR H |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DAP6; EAP1; BING2; SMIM40; Daxx |
Positive Sample: | K-562,SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, PML body |
Calculated MW: | 81kDa |
Observed MW: | 110kDa |
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1616 |
Clone Number: | ARC2220 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |