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Daxx Rabbit Polyclonal Antibody (CAB1642)

SKU:
CAB1642
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DAXX
BING2
DAP6
EAP1
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Daxx Rabbit Polyclonal Antibody
SKU:CAB1642
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 175-400 of human Daxx (NP_001135441.1).
Sequence:ASQS PRTR GSRR QIQR LEQL LALY VAEI RRLQ EKEL DLSE LDDP DSAY LQEA RLKR KLIR LFGR LCEL KDCS SLTG RVIE QRIP YRGT RYPE VNRR IERL INKP GPDT FPDY GDVL RAVE KAAA RHSL GLPR QQLQ LMAQ DAFR DVGI RLQE RRHL DLIY NFGC HLTD DYRP GVDP ALSD PVLA RRLR ENRS LAMS RLDE VISK YAML QDKS EEGE RKKR RARL QG
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:DAP6; EAP1; BING2; SMIM40; Daxx
Positive Sample:K-562,SH-SY5Y
Conjugate:Unconjugated
Cellular Localization:Chromosome, Cytoplasm, Nucleus, PML body, centromere, nucleolus, nucleoplasm.
Calculated MW:81kDa
Observed MW:110kDa

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:1616
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Daxx Rabbit pAb (CAB1642) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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