The Anti-DARPP32 Antibody (CAB4027) is a valuable tool for research involving DARPP32, a key protein involved in signal transduction in the brain. This antibody, produced in rabbits, is highly specific for detecting DARPP32 in human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to DARPP32, researchers can explore its role in various cellular processes and its potential implications in neurological disorders and psychiatric conditions.DARPP32, also known as dopamine- and cAMP-regulated phosphoprotein, is crucial for mediating the effects of neurotransmitters in the brain, particularly dopamine.
Dysregulation of DARPP32 has been linked to conditions such as schizophrenia, bipolar disorder, and drug addiction. Studying the function and regulation of DARPP32 is essential for understanding these complex neurological diseases and developing targeted therapies to address them.Overall, the Anti-DARPP32 Antibody (CAB4027) offers researchers a reliable tool to investigate the role of DARPP32 in brain function and dysfunction, paving the way for new insights and potential therapeutic interventions in neurological and psychiatric disorders.
Product Name:
DARPP32 Rabbit Monoclonal Antibody
SKU:
CAB4027
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DARPP32 (Q9UD71).
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
84152
Clone Number:
ARC2095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DARPP32 Rabbit mAb (CAB4027) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
