Cytokeratin 6 (KRT6) Rabbit Monoclonal Antibody (CAB4631)
- SKU:
- CAB4631
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CK-6C
- CK-6E
- CK6A
- CK6C
- CK6D
- K6A
- K6C
- K6D
- KRT6C
- KRT6D
- PC3
- Research Area:
- Cell Biology
Description
Product Name: | Cytokeratin 6 (KRT6) Rabbit Monoclonal Antibody |
SKU: | CAB4631 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cytokeratin 6 (KRT6) (P02538). |
Sequence: | MAST STTI RSHS SSRR GFSA NSAR LPGV SRSG FSSV SVSR SRGS GGLG GACG GAGF GSRS LYGL GGSK RISI GGGS CAIS GGYG SRAG GSYG FGGA GSGF |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D; Cytokeratin 6 (KRT6) |
Positive Sample: | 5637,A-431 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular exosome, nucleus |
Calculated MW: | 60kDa |
Observed MW: | 60kDa |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Purification Method: | Affinity purification |
Gene ID: | 3853 |
Clone Number: | ARC2142 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |