The Anti-Cytokeratin 16 (KRT16) Antibody (CAB8690) is a high-quality antibody designed for research involving cytokeratin 16, a type I cytokeratin protein expressed in keratinocytes. The antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in immunohistochemistry and Western blot applications. Cytokeratin 16 is involved in the development and maintenance of the skin, particularly in wound healing and hyperproliferative skin disorders. Its overexpression has also been linked to various cancers, including oral squamous cell carcinoma and breast cancer.
This antibody enables the detection and analysis of cytokeratin 16 in various cell types, providing valuable insights for research in dermatology, oncology, and regenerative medicine.Understanding the role of cytokeratin 16 in skin biology and cancer progression is crucial for developing targeted therapies and diagnostic tools. This antibody offers researchers a powerful tool for investigating the function and expression of cytokeratin 16, ultimately advancing our knowledge of skin diseases and cancer pathogenesis.
Product Name:
Cytokeratin 16 Rabbit Monoclonal Antibody
SKU:
CAB8690
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cytokeratin 16 (KRT16) (P08779).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Purification Method:
Affinity purification
Gene ID:
3868
Clone Number:
ARC1783
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse large intestine, using Cytokeratin 16 (KRT16) Rabbit mAb (CAB8690) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
