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CYPOR Rabbit Monoclonal Antibody (CAB5032)

SKU:
CAB5032
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CPR
CYPOR
P450R
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CYPOR Rabbit Monoclonal Antibody
SKU:CAB5032
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human CYPOR (P16435).
Sequence:KDAH RYGM RGMS ADPE EYDL ADLS SLPE IDNA LVVF CMAT YGEG DPTD NAQD FYDW LQET DVDL SGVK FAVF GLGN KTYE HFNA MGKY VDKR LEQL GAQR I
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CPR; CYPOR; P450R
Positive Sample:HeLa,A-549,Mouse lung,Mouse liver,Mouse brain,Rat liver
Conjugate:Unconjugated
Cellular Localization:Endoplasmic reticulum membrane, Peripheral membrane protein.
Calculated MW:77kDa
Observed MW:77kDa

This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase.

Purification Method:Affinity purification
Gene ID:5447
Clone Number:ARC1981
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CYPOR Rabbit mAb (CAB5032) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.

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