The CYP39A1 Polyclonal Antibody (CAB20530) is a valuable tool for researchers studying the cytochrome P450 family of enzymes, specifically focusing on the CYP39A1 protein. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CYP39A1 protein, this antibody enables the detection and analysis of this enzyme in various cell types, making it an essential component for studies in drug metabolism and toxicology.Cytochrome P450 enzymes, including CYP39A1, play a crucial role in the metabolism of drugs and xenobiotics in the liver.
Understanding the function and regulation of CYP39A1 is important for predicting drug interactions, metabolism rates, and toxicity levels in pharmaceutical development. Research on CYP39A1 can also provide insights into the mechanisms of drug resistance and the efficacy of chemotherapy agents in cancer treatment. By utilizing the CYP39A1 Polyclonal Antibody in their experiments, researchers can delve deeper into the intricate pathways of drug metabolism and explore potential therapeutic strategies for various diseases.
Product Name:
CYP39A1 Rabbit Polyclonal Antibody
SKU:
CAB20530
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYP39A1 (NP_057677.2).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51302
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CYP39A1 antibody (CAB20530) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
