The Anti-CYP26A1 Antibody (CAB5982) is a valuable tool for researchers studying the role of the cytochrome P450 26A1 enzyme in various biological processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CYP26A1 protein, this antibody allows for the detection and analysis of CYP26A1 in a variety of cell types, making it an excellent choice for studies in pharmacology, toxicology, and developmental biology.
The cytochrome P450 26A1 enzyme plays a crucial role in the metabolism of retinoic acid, a key regulator of gene expression and cell differentiation. Dysregulation of CYP26A1 has been implicated in various diseases, including cancer, developmental disorders, and vitamin A deficiency. By understanding the function of CYP26A1, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.
Product Name:
CYP26A1 Rabbit Monoclonal Antibody
SKU:
CAB5982
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 201-450 of human CYP26A1 (O43174).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
1592
Clone Number:
ARC2126
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using CYP26A1 Rabbit mAb (CAB5982) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
