The CXCR3 Recombinant Rabbit Monoclonal Antibody (HDAB0199) is a powerful tool for researchers studying CXCR3, a chemokine receptor involved in the regulation of immune responses. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting human CXCR3 protein in various cell types and tissues. Validated for use in applications such as Western blotting, the CXCR3 antibody enables precise detection and analysis of CXCR3 expression levels.CXCR3 is known for its role in regulating immune cell trafficking and inflammation, making it a key target for research in fields such as immunology and oncology.
By understanding the function and expression of CXCR3, researchers can uncover valuable insights into immune response modulation and potentially identify novel therapeutic targets for diseases like cancer, autoimmune disorders, and inflammatory conditions.Overall, the CXCR3 Recombinant Rabbit Monoclonal Antibody (HDAB0199) serves as a valuable tool for researchers seeking to explore the role of CXCR3 in immune regulation and disease pathogenesis. Its high specificity and sensitivity make it an essential component for studies aiming to elucidate the complex mechanisms underlying immune responses and inflammation.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
