CSK Rabbit Monoclonal Antibody (CAB0666)
- SKU:
- CAB0666
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | CSK Rabbit Monoclonal Antibody |
SKU: | CAB0666 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSK (P41240). |
Sequence: | MSAI QAAW PSGT ECIA KYNF HGTA EQDL PFCK GDVL TIVA VTKD PNWY KAKN KVGR EGII PANY VQKR EGVK AGTK LSLM PWFH GKIT REQA ERLL YPPE |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | CSK; tyrosine-protein kinase CSK |
Positive Sample: | A549,Jurkat,Raji,C6,Mouse spleen,Mouse thymus,Rat lung,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 51kDa |
Observed MW: | 48kDa |
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1445 |
Clone Number: | ARC1835 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |