The Anti-CS1 Biotinylated Recombinant Rabbit Monoclonal Antibody (HDAB0221) is a cutting-edge tool for researchers studying CS1, a cell surface glycoprotein involved in immune regulation and cancer progression. This highly specific antibody, developed in rabbits, is optimized for use in various applications, including immunofluorescence and flow cytometry.CS1, also known as SLAMF7, is a potential target for immunotherapy in multiple myeloma and other hematological malignancies. The binding of this antibody to CS1 allows for precise detection and analysis of this protein in both normal and diseased cells, making it a valuable tool for understanding the role of CS1 in immune system function and disease progression.
With its high specificity and sensitivity, the Anti-CS1 Biotinylated Recombinant Rabbit Monoclonal Antibody (HDAB0221) is an essential reagent for researchers exploring the therapeutic potential of targeting CS1 in the treatment of cancer and other immune-related disorders.
SKU:
HDAB0221
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM11
Synonyms:
SLAM7 (19A, CD319, CRACC, CS1)
Applications:
ELISA, Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
