The Anti-CS1 Biotinylated Recombinant Rabbit Monoclonal Antibody (HDAB0189) is a versatile tool for research involving CS1, a cell surface protein that is overexpressed in multiple myeloma and other hematologic malignancies. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards CS1, allowing for accurate detection and analysis in a variety of experimental settings.CS1, also known as SLAMF7, is a key target for antibody-based therapies in multiple myeloma due to its role in promoting tumor cell growth and survival. By targeting CS1 with this antibody, researchers can gain valuable insights into the molecular mechanisms involved in disease progression and potential therapeutic interventions.
In addition to its applications in cancer research, the Anti-CS1 Biotinylated Recombinant Rabbit Monoclonal Antibody is also suitable for immunohistochemistry, flow cytometry, and other techniques commonly used in laboratory settings. Its reliability and reproducibility make it an essential tool for studies aimed at unraveling the complex biology of CS1 and its implications in various disease contexts.
SKU:
HDAB0189
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM10
Synonyms:
SLAM7 (19A, CD319, CRACC, CS1)
Applications:
ELISA, Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
