Creatine kinase B type (CKB) Rabbit Monoclonal Antibody (CAB4907)
The Anti-Creatine Kinase B Type (CKB) Antibody (CAB4907) is a valuable tool for researchers studying creatine kinase B type, an enzyme involved in energy transfer in tissues with high energy demands such as muscle and brain tissue. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.Creatine kinase B type plays a key role in ATP regeneration through the conversion of creatine and ADP to phosphocreatine and ATP. Dysregulation of this enzyme has been implicated in various diseases such as heart failure, neurodegenerative disorders, and muscular dystrophy.
The CKB Antibody enables researchers to detect and analyze levels of creatine kinase B type in different cell types, providing valuable insights into its function and potential therapeutic applications.By understanding the role of creatine kinase B type in energy metabolism and its implications in disease pathology, researchers can develop targeted therapies to address conditions associated with impaired energy production and utilization. The CKB Antibody is a valuable tool for advancing research in the fields of metabolism, neuroscience, and muscle physiology.
Product Name:
Creatine kinase B type (CKB) Rabbit Monoclonal Antibody
SKU:
CAB4907
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Creatine kinase B type (CKB) (NP_001814.2).
BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29; Creatine kinase B type (CKB)
Positive Sample:
HeLa, Mouse brain, Rat brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, cytosol, Mitochondrion, Cell membrane
Calculated MW:
43kDa
Observed MW:
43kDa
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
Purification Method:
Affinity purification
Gene ID:
1152
Clone Number:
ARC1990
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Creatine kinase B type (CKB) Rabbit mAb (CAB4907) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
