The Anti-COX2 (PTGS2) Antibody (CAB3560) is a valuable tool for researchers studying cyclooxygenase-2 (COX2), an enzyme involved in inflammation and pain. This antibody, produced in rabbits, is highly specific to human COX2 protein and is ideal for use in Western blot and immunohistochemistry applications. It binds to COX2, allowing for the detection and analysis of this important enzyme in various cell types.COX2 is a key player in the inflammatory response and is overexpressed in many diseases, including cancer, arthritis, and cardiovascular conditions.
Understanding the role of COX2 and its regulation is essential for developing targeted therapies that can effectively modulate inflammation and pain. The Anti-COX2 (PTGS2) Antibody (CAB3560) provides researchers with a reliable tool to study COX2 expression and activity in both normal and disease conditions, advancing our knowledge of the mechanisms underlying inflammation-related diseases.
Product Name:
Cox2 Rabbit Monoclonal Antibody
SKU:
CAB3560
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 505-604 of human COX2/PTGS2 (P35354).
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Purification Method:
Affinity purification
Gene ID:
5743
Clone Number:
ARC0800
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using COX2/PTGS2 Rabbit mAb (CAB3560) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
