The Anti-CoREST (RCOR1) Antibody (CAB3568) is a valuable tool for researchers studying the CoREST protein, a key component of chromatin remodeling complexes involved in gene regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various experimental applications such as Western blotting and immunohistochemistry.CoREST, also known as Rest Corepressor 1, is essential for controlling neuronal development, synaptic plasticity, and gene expression in the brain.
Dysregulation of CoREST has been linked to neurological disorders such as Alzheimer's disease, autism, and depression, highlighting its importance in understanding brain function and disease mechanisms. By targeting CoREST with the CAB3568 antibody, researchers can gain insights into its role in epigenetic regulation and potential therapeutic strategies for neurological conditions.
Product Name:
CoREST/RCOR1 Rabbit Monoclonal Antibody
SKU:
CAB3568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CoREST/RCOR1 (Q9UKL0).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsChIP,5μg antibody for 10μg-15μg of Chromatin
Synonyms:
RCOR; COREST; CoREST/RCOR1
Positive Sample:
HT-29,HepG2,C2C12
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
53kDa
Observed MW:
65kDa
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
Purification Method:
Affinity purification
Gene ID:
23186
Clone Number:
ARC2044
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CoREST/RCOR1 Rabbit mAb (CAB3568) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
