COPA Monoclonal Antibody (CAB19651)
- SKU:
- CAB19651
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AILJK
- HEP-COP
- Research Area:
- Cell Biology
Description
COPA Rabbit Monoclonal Antibody (CAB19651)
The COPA Polyclonal Antibody (CAB19651) is a valuable tool for researchers studying COPA, a protein involved in trafficking between the Golgi apparatus and the endoplasmic reticulum. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunofluorescence applications. By binding to the COPA protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and protein trafficking.COPA plays a crucial role in maintaining cellular homeostasis by facilitating the transport of proteins and lipids within the cell. Dysregulation of COPA function has been implicated in various diseases, including autoimmune disorders and neurodegenerative conditions.
Therefore, studying the role of COPA and its interactions with other cellular components is essential for understanding disease pathology and identifying potential therapeutic targets.Overall, the COPA Polyclonal Antibody (CAB19651) is a reliable reagent for researchers interested in exploring the intricate mechanisms of protein trafficking and its implications in disease development. Its specificity and sensitivity make it a valuable asset in advancing our knowledge of cellular processes and identifying novel therapeutic strategies.
| Product Name: | COPA Rabbit Monoclonal Antibody |
| SKU: | CAB19651 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human COPA (P53621). |
| Sequence: | MLTK FETK SARV KGLS FHPK RPWI LTSL HNGV IQLW DYRM CTLI DKFD EHDG PVRG IDFH KQQP LFVS GGDD YKIK VWNY KLRR CLFT LLGH LDYI RTTF |
| Tested Applications: | WB IHC-P ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
| Synonyms: | AILJK; HEP-COP; alpha-COP; COPA |
| Positive Sample: | HeLA,HT-29,MCF7,Mouse lung,Rat brain |
| Conjugate: | Unconjugated |
| Cellular Localization: | COPI vesicle coat, cytoplasm, cytosol, extracellular exosome, extracellular space, transport vesicle |
| Calculated MW: | 138kDa |
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
| Purification Method: | Affinity purification |
| Gene ID: | 1314 |
| Clone Number: | ARC2215 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using COPA Rabbit mAb (CAB19651) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s. |
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