The Anti-Cofilin Antibody (CAB2658) is a valuable tool for researchers studying cofilin, a key regulator of actin dynamics in cells. This polyclonal antibody, derived from rabbit immunization, demonstrates high reactivity with cofilin protein in human samples and has been validated for Western blot applications. By specifically binding to cofilin, this antibody enables precise detection and analysis of cofilin expression in a variety of cell types, making it an essential component for studies in cell biology and cancer research.Cofilin is a critical protein involved in the reorganization of actin filaments, playing a crucial role in cell migration, division, and signaling processes.
Dysregulation of cofilin activity has been implicated in various diseases, including cancer metastasis and neurological disorders. By accurately assessing cofilin levels and activity, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the Anti-Cofilin Antibody (CAB2658) offers researchers a reliable tool for investigating cofilin function and its implications in cellular processes and disease pathology. Its specificity and sensitivity make it an essential resource for advancing our understanding of cofilin biology and its potential therapeutic applications.
Product Name:
Cofilin Rabbit Monoclonal Antibody
SKU:
CAB2658
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cofilin (P23528).
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
Purification Method:
Affinity purification
Gene ID:
1072
Clone Number:
ARC2615
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cofilin antibody (CAB2658) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
