The Anti-Clock Antibody (CAB7265) is a high-quality polyclonal antibody designed for research involving the CLOCK protein, a key regulator of circadian rhythms and biological processes. The antibody, raised in rabbits, offers high reactivity with human samples and has been validated for use in various applications, including Western blotting. By specifically binding to the CLOCK protein, this antibody allows for accurate detection and analysis in different cell types, making it an ideal tool for studies in chronobiology and related fields. The CLOCK protein plays a crucial role in the control of circadian rhythms and the regulation of physiological processes such as sleep-wake cycles, metabolism, and gene expression. Dysregulation of the CLOCK protein has been linked to disruptions in circadian rhythms, which can contribute to various health conditions, including sleep disorders, metabolic disorders, and mental health issues.
By studying the activity of the CLOCK protein, researchers can gain insights into the underlying mechanisms of these disorders and potentially develop novel therapeutic strategies for their treatment. Overall, the Anti-Clock Antibody (CAB7265) is a valuable tool for researchers interested in understanding the role of CLOCK protein in circadian biology and its implications for human health. Its high specificity and reactivity make it a reliable choice for studies aiming to uncover the intricate workings of circadian rhythms and their impact on various physiological processes.
Product Name:
CLOCK Rabbit Monoclonal Antibody
SKU:
CAB7265
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CLOCK (NP_004889.1).
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9575
Clone Number:
ARC1819
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLOCK Rabbit mAb (CAB7265) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
