Anti-CLEC4E Antibody (CAB20156)
- SKU:
- CAB20156
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MINCLE
- CLECSF9
Description
Anti-CLEC4E Antibody (CAB20156)
The CLEC4E Polyclonal Antibody (CAB20156) is a valuable tool for researchers studying CLEC4E, a cell surface receptor involved in immune responses and inflammation. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the CLEC4E protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for detailed research in immunology and cancer biology.CLEC4E, also known as C-type lectin domain family 4 member E, is a crucial player in immune regulation and inflammatory processes.
Its role in mediating immune responses makes it a promising target for research on diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of CLEC4E is essential for the development of treatments that modulate immune responses in these disease contexts, making this antibody an essential tool for researchers aiming to uncover new therapeutic strategies.
Product Name: | CLEC4E Rabbit pAb |
Product Code: | CAB20156 |
Size: | 50uL, 100uL |
Synonyms: | MINCLE, CLECSF9 |
Applications: | WB |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human CLEC4E. |
Applications: | WB |
Recommended Dilutions: | WB 1:1000 - 1:2000 |
Reactivity: | Mouse, Rat |
Positive Samples: | Mouse spleen, Rat spleen |
Immunogen: | Recombinant protein of human CLEC4E. |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 26253 |
Uniprot: | Q9ULY5 |
Calculated MW: | 25kDa |
Observed MW: | 27KDa |
UniProt Protein Function: | CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: integral to membrane; plasma membrane Molecular Function:carbohydrate binding; receptor activity Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response |
NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9ULY5 |
NCBI GenInfo Identifier: | 7657333 |
NCBI Gene ID: | 26253 |
NCBI Accession: | NP_055173.1 |
UniProt Secondary Accession: | Q9ULY5,B2R6Q6, |
UniProt Related Accession: | Q9ULY5 |
Molecular Weight: | 25,073 Da |
NCBI Full Name: | C-type lectin domain family 4 member E |
NCBI Synonym Full Names: | C-type lectin domain family 4 member E |
NCBI Official Symbol: | CLEC4E |
NCBI Official Synonym Symbols: | MINCLE; CLECSF9 |
NCBI Protein Information: | C-type lectin domain family 4 member E |
UniProt Protein Name: | C-type lectin domain family 4 member E |
UniProt Synonym Protein Names: | C-type lectin superfamily member 9; Macrophage-inducible C-type lectin |
Protein Family: | C-type lectin domain family |
UniProt Gene Name: | CLEC4E |
UniProt Entry Name: | CLC4E_HUMAN |