The Anti-CLDN6 Antibody (CAB20465) is a valuable tool for researchers studying CLDN6, a member of the claudin protein family involved in tight junction formation and epithelial barrier function. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blotting, immunofluorescence, and immunohistochemistry applications.CLDN6 is known to be overexpressed in various cancer types, making it a potential therapeutic target for cancer treatment. By using this antibody, researchers can detect and study the expression of CLDN6 in different cell types and tissues, providing valuable insights into its role in cancer progression and metastasis.
Furthermore, the Anti-CLDN6 Antibody can also be used in studies related to epithelial cell biology, barrier function, and developmental biology. Its high specificity and sensitivity make it a reliable tool for investigating the function and localization of CLDN6 in various physiological and pathological conditions.
Product Name:
CLDN6 Rabbit Polyclonal Antibody
SKU:
CAB20465
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 121-220 of human Claudin 6 (NP_067018.2).
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Purification Method:
Affinity purification
Gene ID:
9074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of OVCAR3 cells, using Claudin 6 antibody (CAB20465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
