The CHMP2B Polyclonal Antibody (CAB19244) is a valuable tool for researchers studying CHMP2B, a protein involved in the endosomal sorting complex required for transport (ESCRT) pathway. This antibody, produced in rabbits, is highly specific to human samples and is recommended for use in Western blot applications. By binding to the CHMP2B protein, this antibody enables the detection and analysis of CHMP2B in various cell types, making it ideal for research in cell biology and neurodegenerative diseases.CHMP2B is a key player in the ESCRT pathway, which is responsible for sorting and trafficking proteins within cells.
Dysregulation of this pathway has been linked to neurodegenerative disorders such as frontotemporal dementia and amyotrophic lateral sclerosis. By studying CHMP2B, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets.Overall, the CHMP2B Polyclonal Antibody is a powerful tool for investigating the role of CHMP2B in cellular processes and its implications for neurodegenerative diseases. Its high specificity and sensitivity make it a valuable asset for researchers working in these areas of study.
Product Name:
CHMP2B Rabbit Monoclonal Antibody
SKU:
CAB19244
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 114-213 of human CHMP2B (Q9UQN3).
Cytoplasm, Late endosome membrane, Peripheral membrane protein, Cytosol.
Calculated MW:
24kDa
Observed MW:
28kDa
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
Purification Method:
Affinity purification
Gene ID:
25978
Clone Number:
ARC2404
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHMP2B Rabbit mAb (CAB19244) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
