The CHM Polyclonal Antibody (CAB9378) is a valuable tool for researchers studying the CHM protein, which is involved in the progression of cancer. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CHM protein, researchers can easily detect and analyze its expression in various cell types.CHM, also known as CHM protein or REP1, plays a crucial role in regulating membrane trafficking pathways and cellular functions. Dysregulation of CHM has been linked to cancer progression, making it a potential therapeutic target for cancer treatment.
Understanding the role of CHM in cancer biology can provide valuable insights for developing targeted therapies against this devastating disease.Overall, the CHM Polyclonal Antibody (CAB9378) is an essential tool for researchers investigating the role of CHM in cancer development and progression. Its high reactivity and specificity make it an ideal choice for immunological studies and cancer research applications.
Product Name:
CHM Monoclonal Antibody
SKU:
CAB9378
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386).
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1121
Clone Number:
ARC2736
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using (CAB9378) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
