The CHD3 Polyclonal Antibody (CAB6118) is a valuable tool for researchers studying chromodomain helicase DNA-binding protein 3 (CHD3), a key player in chromatin remodeling processes. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for human samples, making it suitable for use in Western blot applications.CHD3 is essential for maintaining chromatin structure and regulating gene expression, impacting various cellular processes such as cell differentiation, DNA repair, and development.
Dysregulation of CHD3 has been linked to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities.By targeting CHD3 protein, researchers can investigate its role in epigenetic regulation and explore its potential as a therapeutic target in disease treatment. The CHD3 Polyclonal Antibody is a reliable tool for detecting and studying CHD3 protein levels in different cell types, offering valuable insights into the molecular mechanisms underlying complex biological processes.
Product Name:
CHD3 Rabbit Monoclonal Antibody
SKU:
CAB6118
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHD3 (Q12873).
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
1107
Clone Number:
ARC1975
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHD3 Rabbit mAb (CAB6118) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
