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Anti-CHD1L Antibody (CAB17558)

SKU:
CAB17558
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ALC1
CHDL
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Anti-CHD1L Antibody (CAB17558)

The CHD1L Polyclonal Antibody (CAB17558) is a valuable tool for research involving CHD1L, a chromodomain helicase DNA-binding protein that plays a crucial role in epigenetic regulation and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various applications including Western blotting.CHD1L is a key player in maintaining chromatin structure and regulating gene transcription, making it a significant target for studies in cancer research and chromatin biology.

Its dysregulation has been implicated in various cancers, highlighting its potential as a therapeutic target. By using the CHD1L Polyclonal Antibody, researchers can investigate the role of CHD1L in gene expression, chromatin remodeling, and cancer progression, providing valuable insights for the development of targeted therapies.

Product Name:CHD1L Rabbit mAb
Product Code:CAB17558
Size:20uL, 50uL, 100uL
Synonyms:ALC1, CHDL
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CHD1L
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2
Immunogen:A synthesized peptide derived from human CHD1L
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9557
Uniprot:Q86WJ1
Calculated MW:101kDa
Observed MW:101KDa
UniProt Protein Function:CHD1L: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.6.4.12; Helicase; DNA-binding

Chromosomal Location of Human Ortholog: 1q12

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function:ATP-dependent DNA helicase activity; ATPase activity; nucleotide binding; protein binding

Biological Process: chromatin remodeling; DNA repair; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; response to DNA damage stimulus

NCBI Summary:This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q86WJ1
NCBI GenInfo Identifier:311033359
NCBI Gene ID:9557
NCBI Accession:Q86WJ1.2
UniProt Secondary Accession:Q86WJ1,Q53EZ3, Q5VXX7, Q6DD94, Q6PK83, Q86XH3, Q96HF7 Q96SP3, Q9BVJ1, A5YM64, B4DDE1, B5MDZ7,
UniProt Related Accession:Q86WJ1
Molecular Weight:69,139 Da
NCBI Full Name:Chromodomain-helicase-DNA-binding protein 1-like
NCBI Synonym Full Names:chromodomain helicase DNA binding protein 1 like
NCBI Official Symbol:CHD1L  
NCBI Official Synonym Symbols:ALC1; CHDL  
NCBI Protein Information:chromodomain-helicase-DNA-binding protein 1-like
UniProt Protein Name:Chromodomain-helicase-DNA-binding protein 1-like
UniProt Synonym Protein Names:Amplified in liver cancer protein 1
Protein Family:Chromodomain-helicase-DNA-binding protein
UniProt Gene Name:CHD1L  
UniProt Entry Name:CHD1L_HUMAN

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