The Anti-CFTR Antibody (CAB8386) is a valuable tool for researchers studying Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a protein involved in ion transport and regulation of fluid secretion in various tissues. This antibody, produced in rabbits, shows high reactivity with CFTR in human samples and is validated for use in a variety of applications, including Western blot and immunofluorescence.CFTR is a key player in maintaining the balance of ions and water across cell membranes, particularly in the respiratory and digestive systems. Mutations in the CFTR gene lead to the development of Cystic Fibrosis, a genetic disorder characterized by thick mucus production and impaired organ function.
Studying the expression and function of CFTR can provide insights into disease mechanisms and potential therapeutic targets for managing Cystic Fibrosis.The Anti-CFTR Antibody enables researchers to detect and analyze CFTR protein levels in different cell types, aiding in the investigation of CFTR-related diseases and the development of targeted interventions. Understanding the role of CFTR in ion transport and fluid balance is crucial for advancing our knowledge of Cystic Fibrosis pathology and improving treatment options for affected individuals.
Product Name:
CFTR Rabbit Polyclonal Antibody
SKU:
CAB8386
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 700-840 of human CFTR (NP_000483.3).
Cell membrane, Early endosome membrane, Multi-pass membrane protein.
Calculated MW:
168kDa
Observed MW:
168kDa
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.
Purification Method:
Affinity purification
Gene ID:
1080
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CFTR Rabbit pAb (CAB8386) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
