CFTR Rabbit Polyclonal Antibody (CAB8386)
- SKU:
- CAB8386
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
Product Name: | CFTR Rabbit Polyclonal Antibody |
SKU: | CAB8386 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-840 of human CFTR (NP_000483.3). |
Sequence: | SILN PINS IRKF SIVQ KTPL QMNG IEED SDEP LERR LSLV PDSE QGEA ILPR ISVI STGP TLQA RRRQ SVLN LMTH SVNQ GQNI HRKT TAST RKVS LAPQ ANLT ELDI YSRR LSQE TGLE ISEE INEE DLKE CFFD DMES I |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1; CFTR |
Positive Sample: | 293T,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Early endosome membrane, Multi-pass membrane protein. |
Calculated MW: | 168kDa |
Observed MW: | 168kDa |
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome.
Purification Method: | Affinity purification |
Gene ID: | 1080 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |