The Anti-CENPC Antibody (CAB3975) is a high-quality research tool designed for studying centromeric proteins, specifically CENPC. This polyclonal antibody is produced in rabbits and is highly reactive with human samples, making it a reliable tool for researchers studying centromere function in various cell types.CENPC is a key protein involved in centromere assembly and function, playing a critical role in chromosome segregation during cell division. Mutations or dysregulation of CENPC have been linked to chromosomal instability and cancer development, making it an important target for cancer research.
This antibody is validated for use in Western blot applications, allowing for the detection and analysis of CENPC protein levels in cell lysates. By studying the expression and localization of CENPC, researchers can gain valuable insights into its role in centromere function and its potential implications in diseases such as cancer.Overall, the Anti-CENPC Antibody (CAB3975) is a valuable tool for researchers interested in understanding the molecular mechanisms underlying centromere function and its impact on cell division and disease progression.
Product Name:
CENPC Rabbit Monoclonal Antibody
SKU:
CAB3975
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 380-520 of human CENPC (Q03188).
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.
Purification Method:
Affinity purification
Gene ID:
1060
Clone Number:
ARC2097
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CENPC Rabbit mAb (CAB3975) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
