The Anti-CENPB Antibody (CAB16817) is a highly specific and sensitive tool for research involving the centromere protein B (CENPB), a key protein involved in the organization and function of centromeres. This antibody, generated in rabbits, is optimized for detection of CENPB in human samples, making it a valuable tool for immunohistochemistry and other research applications.CENPB is essential for centromere function, playing a critical role in chromosome segregation and cell division. Aberrant expression or dysfunction of CENPB has been linked to various diseases, including cancer and genetic disorders.
The Anti-CENPB Antibody enables researchers to investigate the expression and localization of CENPB in different cell types and tissues, providing insights into its role in normal and disease states.With its high specificity and sensitivity, the Anti-CENPB Antibody is a reliable tool for studying centromere biology and exploring the potential therapeutic implications of targeting CENPB in disease treatment. Researchers in the fields of cell biology, genetics, and oncology will find this antibody indispensable for their studies on centromere function and its implications for human health.
Product Name:
CENPB Rabbit Polyclonal Antibody
SKU:
CAB16817
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human CENPB (NP_001801.1).
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Purification Method:
Affinity purification
Gene ID:
1059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CENPB Rabbit pAb (CAB16817) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
