The Anti-CDC73 Polyclonal Antibody (CAB0636) is a valuable tool for researchers studying CDC73, a protein involved in the regulation of cell growth and division. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in Western blot applications. By binding to the CDC73 protein, this antibody allows for the detection and analysis of CDC73 in various cell types, making it an ideal choice for studies in cancer research and molecular biology.
CDC73, also known as parafibromin, is a tumor suppressor gene that plays a crucial role in controlling cell proliferation and differentiation. Mutations in the CDC73 gene have been associated with various types of cancer, particularly parathyroid tumors. Understanding the function of CDC73 is essential for developing targeted therapies for these diseases, making the Anti-CDC73 Polyclonal Antibody a valuable tool for researchers in the field.
Product Name:
CDC73 Rabbit Polyclonal Antibody
SKU:
CAB0636
Size:
20uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 435-505 of human HRPT2 / CDC73 (Q6P1J9).
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
Purification Method:
Affinity purification
Gene ID:
79577
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse testis, using HRPT2 / CDC73 Rabbit pAb (CAB0636).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
