CDC42 Rabbit Monoclonal Antibody (CAB19028)
- SKU:
- CAB19028
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | CDC42 Rabbit Monoclonal Antibody |
SKU: | CAB19028 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-191 of human CDC42 (P60953). |
Sequence: | GQED YDRL RPLS YPQT DVFL VCFS VVSP SSFE NVKE KWVP EITH HCPK TPFL LVGT QIDL RDDP STIE KLAK NKQK PITP ETAE KLAR DLKA VKYV ECSA LTQK GLKN VFDE AILA ALEP PEPK KSRR CVLL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TKS; G25K; CDC42Hs; CDC42 |
Positive Sample: | HT-29,PC-3,NIH/3T3,C6,Mouse liver,Mouse brain,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor, Midbody, centrosome, cytoskeleton, microtubule organizing center, spindle. |
Calculated MW: | 21kDa |
Observed MW: | 21kDa |
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
Purification Method: | Affinity purification |
Gene ID: | 998 |
Clone Number: | ARC0484 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |